FluentPlex

irritation

/ˌɪɹ.ɪˈteɪ.ʃən/ noun B2
  1. The act of irritating or annoying. (countable, uncountable) · What irritation causes you to be so moody?
  2. The state of being irritated. (countable, uncountable)
  3. A thing or person that annoys. (countable, uncountable)
  4. A state of inflammation or of painful reaction to cell or tissue damage. (countable, uncountable)
  5. A condition of morbid excitability or oversensitiveness of an organ or part of the body; a state in which the application of ordinary stimuli produces pain or excessive or vitiated action. (countable, uncountable)

Plural irritations

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From the library

Her daughters listened in silence to this effusion, sensible that any attempt to reason with or soothe her would only increase the irritation.
Pride and Prejudice, p. 132 · B2
Bennet’s leaving them together, after a longer irritation than usual about Netherfield and its master, she could not help saying,--
Pride and Prejudice, p. 154 · B2
He had spoken in jesting vein, but the twitching of his bushy eyebrows bespoke his disappointment and irritation.
The Valley of Fear, p. 8 · C1
I had rather not be the man that crossed him!” He was cordial and intimate with Douglas, and he was no less friendly with his wife—a friendship which more than once seemed to cause some irritation to the husband, so that even the servants were able to perceive his annoyance.
The Valley of Fear, p. 25 · C1

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Words, meanings, pronunciations and translations from Wiktionary (CC BY-SA 4.0); how common each word is from wordfreq. Made into this dictionary by FluentPlex.