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antagonist

/ænˈtæɡənɪst/ noun C1
  1. An opponent or enemy.
  2. One who antagonizes or stirs.
  3. A chemical that binds to a receptor but does not produce a physiological response, blocking the action of other agonist chemicals, such as endogenous chemical messengers.
  4. The main character or force opposing the protagonist in a literary work or drama.
  5. A muscle that acts in opposition to another. · A flexor, which bends a part, is the antagonist of an extensor, which extends it.

Plural antagonists

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From the library

Bennet, he offered himself as his antagonist at backgammon.
Pride and Prejudice, p. 76 · B2
You know my powers, my dear Watson, and yet at the end of three months I was forced to confess that I had at last met an antagonist who was my intellectual equal.
The Memoirs of Sherlock Holmes, p. 106 · B2
“An outspoken, honest antagonist is the doctor,” said Holmes.
The Return of Sherlock Holmes, p. 119 · C1
There were no signs of a struggle, nor had the victim any weapon with which he might have wounded an antagonist.
A Study in Scarlet, p. 45 · B2

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Words, meanings, pronunciations and translations from Wiktionary (CC BY-SA 4.0); how common each word is from wordfreq. Made into this dictionary by FluentPlex.