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radical

/ˈɹædɪkəl/ adjective C1
  1. Of or pertaining to the root of a plant.
  2. Of or pertaining to the root of a word.
  3. Produced using the root of the tongue.
  4. Relating to a radix or mathematical root. · a radical quantity; a radical sign
  5. Pertaining to the basic or intrinsic nature of something.
  6. Favoring fundamental change, or change at the root cause of a matter. · His beliefs are radical.
  7. Thoroughgoing; far-reaching. · The spread of the cancer required radical surgery, and the entire organ was removed.
  8. Involving free radicals.
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From the library

For a moment it seemed to me that there must be some radical mistake in my calculations.
The Memoirs of Sherlock Holmes, p. 20 · B2
Although some of his more radical proposals failed to gain traction, these specific alterations resonated deeply with the American public.
Shaping American English, p. 1 · C1
Experts recognized that the fundamental relationship between agriculture and the local ecosystem needed to undergo a radical transformation.
The Dust Bowl: An Ecological Catastrophe, p. 1 · C1
As the migration continued farther north to Chicago, the blues underwent a radical transformation to suit the urban environment.
From the Delta to Memphis, p. 1 · C1

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Words, meanings, pronunciations and translations from Wiktionary (CC BY-SA 4.0); how common each word is from wordfreq. Made into this dictionary by FluentPlex.