irrevocably

Any other person would, perhaps, have been overcome by such an intoxicating draught of praise; but he feared to make for himself a mortal enemy of the police minister, although he saw that Dandré was irrevocably lost.

I knew enough of your disposition to be certain, that had you been absolutely, irrevocably decided against me, you would have acknowledged it to Lady Catherine frankly and openly.”

Irrevocably said;

Their remarkable migration north not only transformed the blues but also irrevocably altered the trajectory of popular music forever.