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downer

/ˈdaʊnɚ/ noun C1
  1. A negative drug trip. (slang) · Normally those pills give me a boost, but last night they gave me a downer.
  2. Any drug that has depressant qualities. (slang)
  3. Something or someone disagreeable, dispiriting or depressing; a killjoy. (slang)
  4. A livestock animal that has collapsed.
  5. A form of industrial action in which workers down tools and refuse to work.

Plural downers

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Words, meanings, pronunciations and translations from Wiktionary (CC BY-SA 4.0); how common each word is from wordfreq. Made into this dictionary by FluentPlex.