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affliction

/əˈflɪk.ʃən/ noun C2
  1. A state of pain, suffering, distress or agony. (countable, uncountable)
  2. Something which causes pain, suffering, distress or agony. (countable, uncountable)

Plural afflictions

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From the library

It is natural enough; this strange chain of domestic afflictions, followed by the no less strange death of his daughter——”
The Count of Monte Cristo, p. 1048 · C1
But I’m glad it’s not rainy today because it’s easier to be cheerful and bear up under affliction on a sunshiny day.
Anne of Green Gables, p. 41 · C1
Boiled pork and greens are so unromantic when one is in affliction.”
Anne of Green Gables, p. 101 · C1
The downfall of some dear hope or plan plunged Anne into “deeps of affliction.” The fulfillment thereof exalted her to dizzy realms of delight.
Anne of Green Gables, p. 168 · C1

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Words, meanings, pronunciations and translations from Wiktionary (CC BY-SA 4.0); how common each word is from wordfreq. Made into this dictionary by FluentPlex.