nuke

1. A nuclear weapon. (US, colloquial)
2. Something that destroys or negates, especially on a catastrophic scale. (US, colloquial)
3. A nuclear power station. (US, colloquial)
4. A vessel such as a ship or submarine running on nuclear power. (US, colloquial)
5. A person (such as a sailor in a navy or a scientist) who works with nuclear weapons or nuclear power. (US, colloquial)
6. An enlisted sailor employed in the nuclear power field. (US, colloquial, slang)
7. A cautionary flag placed on a release to label it as "bad" for some reason or another (e.g., being a dupe of a previous release or containing malware). (US, colloquial)
8. A spell, item or ability that does a large amount of damage over a short period of time. (US, colloquial)

Plural nukes